Description
5-Amino-1MQ (also known as 5-amino-1-methylquinolinium) is a small-molecule synthetic compound belonging to the methylquinolinium class, featuring a quinolinium core with a methyl group attached to the nitrogen at position 1 and an amino substituent at position 5. Its chemical formula for the cation is C₁₀H₁₁N₂⁺, with a molecular weight of approximately 159.21 g/mol (free ion form; commonly supplied as the iodide salt, C₁₀H₁₁IN₂, ~286.11 g/mol, CAS 42464-96-0). This compound is characterized as a selective, cell-permeable inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that catalyzes the S-adenosyl-L-methionine (SAM)-dependent methylation of nicotinamide to form 1-methylnicotinamide (1-MNA). It is utilized in laboratory research to investigate NNMT-mediated pathways in cellular metabolism, methyl-donor dynamics, and related biochemical processes, and is not approved for human use by regulatory agencies such as the FDA.
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